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Lyman-Kutcher-Burman Model (NTCP)
Definition 
The Lyman-Kutcher-Burman model seeks to estimate the probability of complications in healthy tissue (NTCP) by delivering a probability curve according to the dose:
ID:(2715, 0)
Data Model LKB
Image
The typical data of the LKB model are the exponent
Organo | N | M | TD50
Eur-lex.europa.eu eur-lex.europa.eu
Joint and jaw | 0.07 | 0.1 | 72
Femoral head and neck | 0.25 | 0.12 | 65
Thoracic box | 0.1 | 0.21 | 68
Equine Tail | 0.03 | 0,12 | 75
Brain | 0.25 | 0.15 | 60
Brain, brain stem | 0.16 | 0.14 | 65
Colon | 0.17 | 0.11 | 55
Heart | 0.35 | 0.1 | 48
Laryngeal-laryngeal edema | 0.11 | 0.075 | 80
Esophagus | 0.06 | 0,11 | 68
Stomach | 0.15 | 0.14 | 65
Liver | 0.32 | 0.15 | 40
Small Intestine | 0.15 | 0.16 | 55
Lens | 0.3 | 0.27 | 18
Spinal cord | 0.05 | 0.175 | 66.5
Cartilage necrosis of the larynx | 0.08 | 0.17 | 70
Optic nerve | 0.25 | 0.14 | 65
Ear, Acute Serous Otitis | 0,01 | 0.15 | 40
Ear, chronic otitis | 0.01 | 0.095 | 65
Parótida | 0.7 | 0,18 | 46
Leather | 0.1 | 0.12 | 70
Brachial plexus | 0.03 | 0.12 | 75
Lungs (both combined) | 0.87 | 0.18 | 24.5
Optical chiasm | 0.25 | 0.14 | 65
Rectum | 0.12 | 0,15 | 80
Retina | 0.2 | 0,19 | 65
Kidney | 0.7 | 0.1 | 28
Thyroid | 0.22 | 0.26 | 80
Bladder | 0.5 | 0.11 | 80
From Burman C, Kutcher G J, Emami B and Goitein M 1991 Fitting of normal tissue tolerance data to an analytic function Int. J. Radiat. Oncol. Biol. Phys.
ID:(8816, 0)
Brief Review of the Lyman-Kutcher-Burman model (LBK)
Description
Variables
Calculations
to 
,
then, select the variable: 
to 
Calculations
Variable
Given
Calculate
Target :
Equation
To be used
Equations
Examples
The Lyman-Kutcher-Burman model seeks to estimate the probability of complications in healthy tissue (NTCP) by delivering a probability curve according to the dose:
(ID 2715)
The estimation of the probability of complications in the Lyman Kutcher Burman Model (LKB) assuming that the probability of failure can be represented as a gauseana around dose
| $NTCP=\displaystyle\frac{1}{\sqrt{2\pi}}\int_{-\infty}^t e^{-u^2/2}du$ |
(ID 4699)
The probability of failure of an organ is estimated based on the deviation of the effective dose calculated for the healthy tissue
| $ t =\displaystyle\frac{ D_{eff} - TD_{50} }{ mTD_{50} }$ |
The
(ID 4846)
The dose is calculated by considering the fraction of the
Thus, the effective dose is:
| $D_{eff}=\left(\sum_iv_iD_i^{1/n}\right)^n$ |
where
(ID 4708)
The typical data of the LKB model are the exponent
Organo | N | M | TD50
Eur-lex.europa.eu eur-lex.europa.eu
Joint and jaw | 0.07 | 0.1 | 72
Femoral head and neck | 0.25 | 0.12 | 65
Thoracic box | 0.1 | 0.21 | 68
Equine Tail | 0.03 | 0,12 | 75
Brain | 0.25 | 0.15 | 60
Brain, brain stem | 0.16 | 0.14 | 65
Colon | 0.17 | 0.11 | 55
Heart | 0.35 | 0.1 | 48
Laryngeal-laryngeal edema | 0.11 | 0.075 | 80
Esophagus | 0.06 | 0,11 | 68
Stomach | 0.15 | 0.14 | 65
Liver | 0.32 | 0.15 | 40
Small Intestine | 0.15 | 0.16 | 55
Lens | 0.3 | 0.27 | 18
Spinal cord | 0.05 | 0.175 | 66.5
Cartilage necrosis of the larynx | 0.08 | 0.17 | 70
Optic nerve | 0.25 | 0.14 | 65
Ear, Acute Serous Otitis | 0,01 | 0.15 | 40
Ear, chronic otitis | 0.01 | 0.095 | 65
Par tida | 0.7 | 0,18 | 46
Leather | 0.1 | 0.12 | 70
Brachial plexus | 0.03 | 0.12 | 75
Lungs (both combined) | 0.87 | 0.18 | 24.5
Optical chiasm | 0.25 | 0.14 | 65
Rectum | 0.12 | 0,15 | 80
Retina | 0.2 | 0,19 | 65
Kidney | 0.7 | 0.1 | 28
Thyroid | 0.22 | 0.26 | 80
Bladder | 0.5 | 0.11 | 80
From Burman C, Kutcher G J, Emami B and Goitein M 1991 Fitting of normal tissue tolerance data to an analytic function Int. J. Radiat. Oncol. Biol. Phys.
(ID 8816)
ID:(1159, 0)